Figure 21-8
Effect of volatile anesthetics on cerebral blood flow
(CBF) (A) and the cerebral metabolic rate of oxygen
(CMRO2
) (B) in humans. The results are
a composite of CBF and CMR values obtained from a number of separate investigations.
[175]
[297]
[301]
[302]
[304]
[305]
[306]
[307]
[308]
[309]
[310]
[311]
[312]
[313]
[314]
[315]
In these studies, PaCO2
was maintained in the normocapnic range (≅35 to 40 mm Hg) and mean arterial pressure
was supported. In most of the investigations, CBF was measured by the inert gas
technique. This technique measures primarily cortical CBF and, as such, might underestimate
global CBF.
