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Autonomic thermoregulation is impaired during regional anesthesia, and the result is typically intraoperative core hypothermia. Interestingly, this hypothermia is often not
Figure 40-10
Changes in body heat content and distribution of heat
within the body during the core temperature plateau. Elapsed time zero indicates
the onset of arteriovenous shunt vasoconstriction, which causes the plateau. Core
temperature decreased 1.3°C in 2 hours before constriction and then remained
constant. The difference between core temperature and mean body temperature (which
continued to decrease) indicates how much heat was retained in the core thermal compartment
by thermoregulatory vasoconstriction. In this case, 22 ± 8 kcal was constrained
to the core. Results are presented as means ± SD. (Redrawn with
modification from Kurz A, Sessler DI, Christensen R, Dechert M: Heat balance and
distribution during the core-temperature plateau in anesthetized humans. Anesthesiology
83:491–499, 1995.)
Epidural anesthesia[61] [62] and spinal anesthesia[62] [63] each decrease the thresholds triggering vasoconstriction and shivering (above the level of the block) about 0.6°C ( Fig. 40-11 ). Presumably, this decrease does not result from recirculation of neuraxially administered local anesthetic because the impairment is similar during epidural and spinal anesthesia,[61] [62] [63] even though the amount and location of administered local anesthetic differ substantially. Furthermore, lidocaine administered intravenously in doses producing plasma concentrations similar to those occurring during epidural anesthesia has no thermoregulatory effect.[64] Finally, neuraxial administration of 2-chloroprocaine, a local anesthetic that has a plasma half-life near 20 seconds, also impairs thermoregulatory control.[65]
The vasoconstriction and shivering thresholds are comparably decreased during regional anesthesia,[63] thus
Figure 40-11
Spinal anesthesia increased the sweating threshold but
reduced the thresholds for vasoconstriction and shivering. Consequently, the interthreshold
range increased substantially. The vasoconstriction-to-shivering range, however,
remained normal during spinal anesthesia. Results are presented as means ±
SD. (Redrawn from Kurz A, Sessler DI, Schroeder M, Kurz M: Thermoregulatory
response thresholds during spinal anesthesia. Anesth Analg 77:721–726, 1993.)
Because neuraxial anesthesia prevents vasoconstriction and shivering in blocked regions, it is not surprising that epidural anesthesia decreases the maximum intensity of shivering. However, epidural anesthesia also reduces the gain of shivering, which suggests that the regulatory system is unable to compensate for lower body paralysis ( Fig. 40-13 ). [27] Thermoregulatory defenses, once triggered, are thus less effective than usual during regional anesthesia.
Neuraxial anesthesia is frequently supplemented with sedative and analgesic medications. With the exception of midazolam,[36] all significantly impair thermoregulatory control.[22] [28] [70] Such inhibition may be severe when combined with the intrinsic impairment produced by regional anesthesia and other factors, including advanced age and preexisting illness ( Fig. 40-14 ).[11]
Figure 40-12
The number of dermatomes blocked (sacral segments, 5;
lumbar segments, 5; thoracic segments, 12) versus reduction in the shivering threshold
(difference between the control shivering threshold and the spinal shivering threshold).
The shivering threshold was reduced more by extensive spinal blocks than by less
extensive ones (Δ threshold = 0.74 − 0.06 [dermatomes
blocked]; r2
= .58, P
< .006). The curved lines indicate the 95% confidence
intervals for the slope. (Redrawn from Leslie K, Sessler DI: Reduction
in the shivering threshold is proportional to spinal block height. Anesthesiology
84:1327–1331, 1996.)
Figure 40-13
Systemic oxygen consumption without (circles)
and with (squares) epidural anesthesia. The horizontal
standard deviation bars indicate variability in the thresholds among the volunteers;
although errors bars are shown only once in each series, the same temperature variability
applies to each data point. The slopes of the oxygen consumption-versus-core temperature
relationships (solid lines) were determined by linear
regression. These slopes defined the gain of shivering with and without epidural
anesthesia. Gain was reduced 3.7-fold, from -412 mL/min/°C (r2
= .99) to -112 mL/min/°C (r2
=
.96). (Redrawn from Kim J-S, Ikeda T, Sessler D, et al: Epidural
anesthesia reduces the gain and maximum intensity of shivering. Anesthesiology 88:851–857,
1998.)
Figure 40-14
Fifteen patients younger than 80 years (58
± 10 years [mean ± SD]) shivered at 36.1°C
± 0.6°C during spinal anesthesia; in contrast, 8 patients 80
years or older (89 ± 7 years) shivered at a significantly
lower mean temperature, 35.2°C ± 0.8°C. The
shivering thresholds in seven of the ten patients older than 80 years was less than
35.5°C, whereas the threshold equaled or exceeded this value in all the younger
patients. (Redrawn from Vassilieff N, Rosencher N, Sessler DI, Conseiller
C: The shivering threshold during spinal anesthesia is reduced in the elderly.
Anesthesiology 83:1162–1166, 1995.)
Interestingly, core hypothermia during regional anesthesia may not trigger a perception of cold.[61] [71] The reason is that thermal perception (behavioral regulation) is largely determined by skin rather than core temperature. During regional anesthesia, core hypothermia is accompanied by a real increase in skin temperature. The result is typically a perception of continued or increased warmth accompanied by autonomic thermoregulatory responses, including shivering ( Fig. 40-15 ).[61] [71]
Taken together, these data indicate that neuraxial anesthesia inhibits numerous aspects of thermoregulatory control. The vasoconstriction and shivering thresholds
Figure 40-15
Induction of epidural anesthesia at an elapsed time of
15 minutes decreased core temperature and increased thermal comfort as determined
by a 100-mm visual analog scale (VAS). Interestingly, however, maximal thermal comfort
coincided with the minimum core temperature. Results
are presented as means ± SD. TM, tympanic membrane. (Redrawn with
modification from Sessler DI, Ponte J: Shivering during epidural anesthesia. Anesthesiology
72:816–821, 1990.)
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