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Responses in Infants and the Elderly (also see Chapter 59 , Chapter 60 , and Chapter 62 )

Thermoregulatory vasoconstriction is comparably impaired in infants, children, and adults given isoflurane[37] or halothane ( Fig. 40-4 ).[38] In contrast, the vasoconstriction threshold is about 1°C less in patients aged 60 to 80 years than in those between 30 and 50 years old ( Fig. 40-5 ).[39] [40]

Nonshivering thermogenesis does not occur in anesthetized adults, [41] which is unsurprising because this


Figure 40-4 The core thermoregulatory threshold in 23 healthy children and infants undergoing abdominal surgery with halothane anesthesia. Differences among the groups are not statistically significant. Results are presented as means ± SD. (Redrawn from Bissonnette B, Sessler DI: Thermoregulatory thresholds for vasoconstriction in pediatric patients anesthetized with halothane or halothane and caudal bupivacaine. Anesthesiology 76:387–392, 1992.)


Figure 40-5 The vasoconstriction threshold was significantly less in the elderly (33.9 ± 0.6°C) than in younger patients (35.1 ± 0.3°C) during 60% nitrous oxide and isoflurane (0.75% end-tidal concentration). Filled circles indicate the vasoconstriction threshold in each patient; open circles show the mean and standard deviation in each group. (Redrawn from Kurz A, Plattner O, Sessler DI, et al: The threshold for thermoregulatory vasoconstriction during nitrous oxide/isoflurane anesthesia is lower in elderly than young patients. Anesthesiology 79:465–469, 1993.)

response is not particularly important in unanesthetized adults.[14] In contrast to adult humans, nonshivering thermogenesis is an important thermoregulatory response in animals and human infants. However, nonshivering thermogenesis in animals is inhibited by volatile anesthetics,[42] and it fails to increase the metabolic rate in infants anesthetized with propofol.[43]

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