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The Meyer-Overton rule postulates that it is the number of molecules dissolved at the site of anesthetic action, not the types of molecules present, that causes anesthesia. A 0.5 MAC of one agent and a 0.5 MAC of another agent should have the same effect as a 1.0 MAC of either agent. In general, this prediction has been confirmed for clinically employed agents in animals and humans,[91] although slight antagonistic effects are occasionally observed.
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