Figure 39-10 Mean cumulative dose-response curve for pancuronium in two muscles shows that the diaphragm requires approximately twice as much pancuronium as does the adductor pollicis muscle for the same amount of neuromuscular blockade. The depression in muscle response to the first stimulus in TOF nerve stimulation (probit scale) was plotted against dose (log scale). Force of contraction of the adductor pollicis was measured on a force-displacement transducer; response of the diaphragm was measured electromyographically. (From Donati F, Antzaka C, Bevan DR: Potency of pancuronium at the diaphragm and the adductor pollicis muscle in humans. Anesthesiology 65:1, 1986.)