Figure 21-11 Effect of anesthetics on cerebral blood flow (CBF) and cerebral blood volume (CBV). When compared with isoflurane, propofol and pentobarbital effected substantial reductions in CBF. However, CBV reductions were more modest. ^[136] These data indicate that the magnitude of the effect of anesthetic agents on CBF is substantially greater than the effect on CBV. Hence, a reduction in CBF may not lead to equivalent reductions in CBV.