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Figure 3-14
Physiologic model for thiopental in rats. The pharmacokinetics
of distribution into each organ has been individually determined. The components
of the model are linked by zero-order (flow) and first-order (diffusion) processes.
(From Ebling WF, Wada DR, Stanski DR: From piecewise to full physiologic
pharmacokinetic modeling: Applied to thiopental disposition in the rat. J Pharmacokinet
Biopharm 22:259–292, 1994.)
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