Figure 13-36 Disorders of channel function (channelopathies) that cause myasthenic syndromes, myotonias, malignant hyperthermia (MH), and central core disease (CCD). AChE, acetylcholinesterase; DHP receptor, dihydropyridine receptor; MuSk, muscle-specific kinase; nAChR, nicotinic acetylcholine receptor; RyR, ryanodine receptor; SV, synaptic vesicle; VGCC (P/Q), voltage-gated calcium channel (P/Q type); VGCLC, voltage-gated chloride channel; VGKC, voltage-gated potassium channel; VGNC, voltage-gated sodium channel.