Figure 13-15 Disappearance of vecuronium from plasma after a single bolus dose of 0.2 mg/kg, as illustrated by a semilogarithmic plot of the mean concentration versus time for patients with normal hepatic function (filled circles) and cirrhotic patients (open circles). Error bars are the SD for that value. (Redrawn from Lebrault C, Berger JL, D'Hollander AA, et al: Pharmacokinetics and pharmacodynamics of vecuronium [ORG NC 45] in patients with cirrhosis. Anesthesiology 62:601–605, 1985.)