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Figure 13-10
Chemical structure of 430A (a mixed-onium chlorofumarate).
In whole human blood, two pathways of deactivation occur, neither of which is enzymatic:
(1) rapid formation of an apparently inactive cysteine adduction product with cysteine
replacing chlorine and (2) slower hydrolysis of the ester bond adjacent to the chlorine
substitution to chlorofumarate monoester and alcohol.[187]
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