Figure 12-28 Evaluation of three pharmacokinetic parameter sets for propofol. Plotted is the measured-to-predicted concentration ratio for samples obtained during administration of propofol through a target-controlled infusion device programmed with the pharmacokinetics derived by Dyck, Marsh, or Tackley (n = 10 per group). A ratio of 1 means that measured equals predicted. Note that the pharmacokinetic parameters of Dyck provide a consistently positive bias.