Figure 11-9 Infarct sizes in rat hearts subjected to control conditions (CON), ischemic preconditioning (PC), glibenclamide (0.3 mg/kg IV) given 30 minutes before ischemic PC (GLY + PC), morphine-induced PC (3 × 100 µg/kg, 5 minutes of IV infusion) (MOR PC), naloxone (3 mg/kg IV) given 10 minutes before morphine-induced PC (NL + MOR PC), and glibenclamide (0.3 mg/kg IV) given 30 minutes before morphine-induced PC (GLY + MOR PC). (From Schultz JE, Hsu AK, Gross GJ: Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circ Res 78:1100–1104, 1996.)