Figure 8-6 Proposed pathways for the CYP2E1-catalyzed metabolism of halothane, enflurane, isoflurane, and desflurane to acylated hepatic proteins. For halothane, isoflurane, and desflurane, the trifluoroacetylated protein adducts are identical in structure, but for enflurane, the adduct is immunologically similar.


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