Figure 7-20 Schematic illustration of canine myocardium subjected to a 60-minute coronary artery occlusion and reperfusion and then stained to identify the region of myocardial infarction (black area) within the area of myocardium at risk for infarction (light gray area). Isoflurane decreased the extent of myocardial infarction. The protective effect of isoflurane was equivalent to that produced by ischemic preconditioning and was abolished by pretreatment with glyburide. *, Significantly (P < .05) different from the control. (Adapted from Kersten JR, Schmeling TJ, Pagel PS, et al: Isoflurane mimics ischemic preconditioning via activation of K_ATP channels. Reduction of myocardial infarct size with an acute memory phase. Anesthesiology 87:361–370, 1997.)