Figure 7-6 Left ventricular (LV) diastolic transmural pressure versus Lagrangian strain relationships in conscious (squares) and halothane-anesthetized (triangles) dogs. The pressure-strain relationship was not altered by halothane anesthesia, indicating that this volatile anesthetic does not affect intrinsic myocardial stiffness. α, Gain; β, modulus of myocardial stiffness. (Adapted from Van Trigt P, Christian CC, Fagraeus L, et al: The mechanism of halothane-induced myocardial depression: Altered diastolic mechanics versus impaired contractility. J Thorac Cardiovasc Surg 85:832–838, 1983.)