Figure 77-16 Effect of sepsis on the rate of protein synthesis (A), RNA concentration (B), and translational efficiency (C) in gastrocnemius (gastroc), psoas, soleus, and heart muscles. Open bars represent control animals, shaded bars represent animals with septic abscess (5 days after fecal-agar pellet infected with Escherichia coli plus Bacteroides fragilis implanted intraperitoneally.) (Adapted from Vary TC, Kimball SR: Sepsis-induced changes in protein synthesis: Differential effects on fast and slow-twitch muscles. Am J Physiol 262:C1513, 1992.)