Figure 7-2 Preload recruitable stroke work (PRSW) slope for chronically instrumented dogs during control and at 1.0 and 1.5 end-tidal minimum alveolar concentrations (MAC) of desflurane (top) and isoflurane (bottom). Insets depict percent changes from control values. *, Significantly (P < .05) different from controls; †, significantly (P < .05) different from 1.0 MAC. (From Pagel PS, Kampine JP, Schmeling WT, Warltier DC: Influence of volatile anesthetics on myocardial contractility in vivo: Desflurane versus isoflurane. Anesthesiology 74:900–907, 1991.)