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Figure 68-8
Computer simulation of the "context-sensitive" half-life
time (CSHT) for remifentanil (3.65 minutes), alfentanil (58.5 minutes), sufentanil
(240 minutes), and fentanyl (262.5 minutes). Note that remifentanil's CSHT is independent
of the duration of infusion. (Redrawn with modification from Egan TD, Lemmens
HJ, Fiset P, et al: The pharmacokinetics of the new short-acting opioid remifentanil
(G187084B) in healthy adult male volunteers. Anesthesiology 79:881, 1993.)
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