Figure 55-3 Influence of low- and high-dose desflurane, halothane, and isoflurane on total hepatic blood flow (THBF) as measured with radioactive microspheres in chronically instrumented dogs. In contrast to desflurane and isoflurane, which increased THBF, halothane caused a significant decrease in THBF at high doses. *Significantly different from conscious control (P < 0.05). (Data from Hartman JC, Pagel PS, Proctor LT, et al: Influence of desflurane, isoflurane and halothane on regional tissue perfusion in dogs. Can J Anaesth 39:877–887, 1992.)