Figure 55-1 Impact of halothane, enflurane, isoflurane, and sevoflurane at 1.0 and 2.0 minimum alveolar concentration (MAC) on total hepatic blood flow (THBF) in dogs. THBF decreased with increasing anesthetic concentrations of each volatile agent. Sevoflurane and isoflurane were similar in their modest effect on THBF, whereas halothane caused a dramatic decrease in THBF, especially at 2-MAC exposure. *Differs from sevoflurane and isoflurane at comparable MAC values (P < .05). (Data from Frink EJ, Morgan SE, Coetzee A, et al: The effects of sevoflurane, halothane, enflurane, and isoflurane on hepatic blood flow and oxygenation in chronically instrumented greyhound dogs. Anesthesiology 76:85–90, 1992.)