Figure 6-2
Effect of isoflurane (A)
and sevoflurane (B) on porcine tracheal versus bronchial
smooth muscle tension or inward Ca2+
current (ICa) through T-type and
L-type voltage-dependent Ca2+
channels (VDCs). There were no differences
in the inhibition of L-type VDCs. Both anesthetics had greater inhibitory effects
on T-type VDCs in bronchial smooth muscle. Symbols represent the mean ± SD.
*P < .05 versus 0 MAC. †P
< .05 versus tracheal smooth muscle in A and †P
< .05 versus L-type VDCs in B. (Adapted
from Yamakage M, Chen X, Tsuijiguchi N, et al: Different inhibitory effects of volatile
anesthetics on T- and L-type voltage-dependent Ca2+
channels in porcine
tracheal and bronchial smooth muscles. Anesthesiology 94:683, 2001.)
