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SUGGESTED READING

Boroujerdi M: Pharmacokinetics. New York, McGraw-Hill, 2002.

Bowdle TA, Horita A, Kharasch ED: The Pharmacologic Basis of Anesthesiology. New York, Churchill Livingstone, 1994.

Chalmers DT, Behan DP: The use of constitutively active GPCRs in drug discovery and functional genomics. Nat Rev Drug Discov 1:599–608, 2002.

Clarke WP, Bond RA: The elusive nature of intrinsic efficacy. Trends Pharmacol Sci 19:270–276, 1998.

Conti-Tronconi BM, McLane KE, Raftery MA, et al: The nicotinic acetylcholine receptor: Structure and autoimmune pathology. Crit Rev Biochem Mol Biol 29:69–123, 1994.

Eckhart AD, Koch WJ: Transgenic studies of cardiac adrenergic receptor regulation. J Pharmacol Exp Ther 299:1–5, 2001.

Eger EI: Anesthetic Uptake and Action. Baltimore, Williams & Wilkins, 1974.

Freedman NJ, Lefkowitz RJ: Desensitization of G protein-coupled receptors. Recent Prog Horm Res 51:319–351, 1996.

Greco WR, Bravo G, Parsons JC: The search for synergy: A critical review from a response surface perspective. Pharmacol Rev 47:331–385, 1995.

Hamm HE: The many faces of G protein signaling. J Biol Chem 273:669–672, 1998.

Jenkinson DH, Barnard EA, Hoyer D, et al: International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. IX. Recommendations on terms and symbols in quantitative pharmacology. Pharmacol Rev 47:255–266, 1995.

Kalow W: Pharmacogenetics in biological perspective. Pharmacol Rev 49:369–379, 1997.

Kenakin T: Efficacy at G-protein-coupled receptors. Nat Rev Drug Discov 1:102–110, 2002.

Kenakin T: Inverse, protean, and ligand-selective agonism: Matters of receptor conformation. FASEB J 15:598–611, 2001.

Kenakin T, Onaran O: The ligand paradox between affinity and efficacy: Can you be there and not make a difference? Trends Pharmacol Sci 23:275–280, 2002.

Krumins AM, Barber R: The stability of the agonist beta2 -adrenergic receptor-Gs complex: Evidence for agonist-specific states. Mol Pharmacol 52:144–154, 1997.

Lambert JJ, Belelli D, Hill-Venning C, et al: Neurosteroid modulation of native and recombinant GABAA receptors. Cell Mol Neurobiol 6:155–174, 1996.

Landry Y, Gies JP: Heterotrimeric G proteins control diverse pathways of transmembrane signaling, a base for drug discovery. Mini Rev Med Chem 2:361–372, 2002.

Liu JG, Anand KJ: Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence. Brain Res Rev 38:1–19, 2001.

Perry SJ, Lefkowitz RJ: Arresting developments in heptahelical receptor signaling and regulation. Trends Cell Biol 12:130–138, 2002.

Pierce KL, Premont RT, Lefkowitz RJ: Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3:639–650, 2002.

Rathz DA, Gregory KN, Fang Y, et al: Hierarchy of polymorphic variation and desensitization permutations relative to beta-1 and beta-2 adrenergic signaling. J Biol Chem 278:10784–10789, 2003.

Rescigno A: Foundations of Pharmacokinetics. New York, Plenum Press, 2003.

Rockman HA, Koch WJ, Lefkowitz RJ: Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J Physiol 272:H1553–H1559, 1997.

Rogers JF, Nafziger AN, Bertino JS Jr: Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs. Am J Med 113:746–750, 2002.

Ross EM, Kenakin TP: Pharmacodynamics: Mechanisms of drug action and the relationship between drug concentration and effect. In Hardman JG, Limbird LE (eds): The Pharmacological Basis of Therapeutics, 10th ed. New York, McGraw-Hill, 2002, pp 31–43.

Rowland M, Tozer TN: Clinical Pharmacokinetics: Concepts and Applications, 3rd ed. Baltimore, Williams & Wilkins, 1995.

Schwinn DA (ed): Scientific Principles of Anesthesia, vol 2. Philadelphia, Current Medicine, 1997.

Shuldiner AR: Transgenic animals. N Engl J Med 334:653–655, 1996.

Skiba NP, Hamm HE: How Gsα activates adenylyl cyclase. Nat Struct Biol 5:88–92, 1998.

Svoboda P, Novotny J: Hormone-induced subcellular redistribution of trimeric G proteins. Cell Mol Life Sci 59:501–512, 2002.

Tang WJ, Hurley JH: Catalytic mechanism and regulation of mammalian adenylyl cyclases. Mol Pharmacol 54:231–240, 1998.

Tucek S, Michal P, Vlachova V: Modelling the consequences of receptor-G-protein promiscuity. Trends Pharmacol Sci 23:171–176, 2002.

Vaughan M: Signaling by heterotrimeric G proteins minireview series. J Biol Chem 273:667–668, 1998.

Watson J, Gilman M, Witkowski J, et al: Recombinant DNA, 2nd ed. New York, WH Freeman, 1992.

Weinshilboum R: Inheritance and drug response. N Engl J Med 348:529–537, 2003.

Wilkinson GR: Pharmacokinetics: The dynamics of drug absorption, distribution, and elimination. In Hardman JG, Limbird LE (eds): The Pharmacological Basis of Therapeutics, 10th ed. New York, McGraw-Hill, 2002, pp 3–29.

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