KEY POINTS
- An increased understanding of the molecular pharmacology of opioid receptors
and opioid-induced cellular responses allows utilization of new innovative techniques
for analgesia.
- Regretfully, the opioids have non-opioid effects on many organ systems,
such as the cardiovascular system. Proper dosing and monitoring allows these effects
to be minimized, when used in humans. Opioids generally induce nausea and vomiting,
the mechanisms of which are clearly identified and now treatable.
- New pharmacokinetic principles have allowed a more intelligent use of opioids,
with more predictable durations of action.
- Surrogate measures of opioid potency allows more accurate dosing devices
for the production of analgesia.
- During total intravenous anesthesia, the use of opioids is a vital part
of providing the analgetic component of anesthesia. Short-acting drugs, such as
remifentanil, allow dissipation of total intravenous anesthetic even more rapidly
than that from inhaled anesthetics.
- New opioid delivery systems, such as transdermal fentanyl patches, are
continually being developed, which allows more flexibility in providing analgesia,
both inside and outside the operating room.
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