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Reduction in Ambient Pressure

Acute ascent to altitude can result in bubbles forming within tissues as a result of local supersaturation of inert gas. Although symptoms of decompression illness have been reported to occur after rapid ascent in aircraft to just 2437 m,[258] they usually occur only in aircraft in which ascent exceeds 5000 to 6000 m.[259] After scuba diving, exposure to lower altitudes (2400 m or less) within 12 to 24 hours can precipitate decompression illness.[260] To reduce the risk of decompression illness, it is the practice of individuals planning a rapid decompression to low ambient pressure (e.g., military pilots, astronauts) to denitrogenate their tissues by prebreathing 100% O2 for periods ranging from a few minutes to several hours, depending on the altitude of the planned exposure.

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