KEY POINTS
- Volatile anesthetics produce dose-related depression of LV, RV, and LA
myocardial contractility, LV diastolic function, and LV-arterial coupling in the
normal heart.
- Negative inotropic effects of volatile anesthetics are related to alterations
in intracellular Ca2+
homeostasis within the cardiac myocyte.
- Volatile anesthetics affect the determinants of LV afterload to varying
degrees in the presence of normal and dysfunctional myocardium.
- Systemic hemodynamic effects of volatile anesthetics are complex and determined
by the interaction of myocardial effects, direct actions on the arterial and venous
vasculature, and alterations in autonomic nervous system activity.
- Volatile anesthetics sensitize myocardium to the arrhythmogenic effects
of epinephrine to varying degrees and may prevent or facilitate the development of
atrial or ventricular arrhythmias during myocardial ischemia or infarction, depending
upon the concentration of the agent, the extent of the injury, and the location affected
within the conduction pathway.
- Volatile anesthetics are relatively weak coronary vasodilators that are
not capable of producing coronary steal at typically used clinical concentrations,
even in patients with steal-prone coronary anatomy.
- Volatile anesthetics exert important cardioprotective effects against reversible
and irreversible myocardial ischemia in experimental animals and humans by activating
intracellular signal transduction pathways involving A1
receptors, PKC,
Gi
proteins, mitochondrial or sarcolemmal KATP
channels, and
ROS.
- Volatile agents depress baroreceptor reflex control of arterial pressure
to varying degrees.
- Nitrous oxide causes direct negative inotropic effects, does not substantially
affect LV diastolic function, and produces modest increases in pulmonary and systemic
arterial pressure via a sympathomimetic effect. These actions are dependent to some
degree upon the baseline anesthetic.
- Xenon is essentially devoid of cardiovascular effects.
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