Figure 5-7 If unopposed by a concomitant increase in ventilation, an increase in cardiac output will decrease alveolar anesthetic concentration by augmenting uptake. The resulting alveolar anesthetic change is greatest with the most soluble anesthetic. FA/FI is the alveolar concentration of anesthetic/concentration of inspired anesthetic. (Adapted from Eger EI II: Ventilation, circulation and uptake. In Eger EI II [ed]: Anesthetic Uptake and Action. Baltimore, Williams & Wilkins, 1974, pp 122–145.)