Figure 40-24 Change in core temperature after the administration of 50,000 IU/kg of interleukin-2 (IL-2) followed by a second dose of 100,000 IU/kg 2 hours later. The first dose of IL-2 defined elapsed time zero; anesthesia was started after 3 elapsed hours and continued for 5 hours. Data are presented as means ± SD. MAC, minimum alveolar concentration. (Redrawn from Negishi C, Lenhardt R, Sessler DI, et al: Desflurane reduces the febrile response to interleukin-2 administration. Anesthesiology 88:1162–1169, 1998.)