Figure 38-16 Influence of isoflurane alone on brainstem auditory evoked potentials in a typical subject. Latency of peaks III and IV to V increased at 1.0% but stabilized with increasing anesthetic depth. (Adapted from Manninen PH, Lam AM, Nicholas JF: The effects of isoflurane-nitrous oxide anesthesia on brainstem auditory evoked potentials in humans. Anesth Analg 64:43, 1985.)