Figure 4-8
The D-stereoisomer (closed
squares) of the α2
-adrenergic agonist medetomidine causes
a dose-dependent decrease in the halothane minimum alveolar concentration (MAC) in
dogs, whereas the L-stereoisomer (open
squares) has little or no influence on halothane MAC. Asterisks
indicate values that are significantly different from the controls. (Adapted
from Vickery RG, Sheridan BC, Segal IS, et al: Anesthetic and hemodynamic effects
of the stereoisomers of medetomidine, an α2
-adrenergic agonist,
in halothane-anesthetized dogs. Anesth Analg 67:611, 1988.)
