Figure 31-14
Interaction surface for fentanyl and isoflurane reflecting
suppression of the autonomic response. The surface is based on the isoflurane interaction
reported by McEwan and colleagues,[23]
but modified
to increase the C50
of isoflurane in the absence of fentanyl by 1.3 and
adjusting the isoflurane C50
in the presence of an effect-site fentanyl
concentration of 1.36 (corresponding to a 1.5-mg/kg bolus) to 0.4 MAC, as reported
by Daniel.[37]
The black arrow
shows the reduction in MACBAR
demonstrated by Daniel and associates.[37]
