Figure 13-31 Comparative mean speed of antagonism by neostigmine of neuromuscular blockade induced by long-acting drugs (doxacurium, pancuronium, pipecuronium), intermediate-acting drugs (atracurium and others), and the short-acting drug mivacurium. Antagonism is more rapid as processes of clearance increase (see text). (Redrawn from Savarese JJ: Reversal of nondepolarizing blocks: More controversial than ever? Review Course Lectures, 67th Congress, Cleveland, Ohio, International Anesthesia Research Society, 1993.)