Figure 13-29 Recovery times (mean ± SD) after administration of a single dose of 0.45 mg/kg (1.5 × ED₉₅ ) rocuronium. In one group (Spont), spontaneous recovery is allowed. In the remaining groups, 70 µg/kg neostigmine is administered 5 minutes after rocuronium or at 1%, 10%, and 25% recovery of the first twitch (T1) from its control value. *P < 0.01 versus spontaneous recovery. Note that times to attain a train-of-four ratio of 0.9 are significantly shorter when neostigmine is administered at T1 = 10% or 25% of control tension. (Figure constructed based on data redrawn from Bevan JC, Collins L, Fowler C, et al: Early and late reversal of rocuronium and vecuronium with neostigmine in adults and children. Anesth Analg 89:333–339, 1999.)