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Figure 13-25
Muscarinic (M3
) receptors are located postsynaptically
on airway smooth muscle. Acetylcholine (ACh) stimulates M3
receptors
to cause contraction. M2
muscarinic receptors are located presynaptically
at the postganglionic parasympathetic nerve endings, and they function in a negative-feedback
mechanism to limit the release of acetylcholine.
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