Figure 13-24 Dose response to mivacurium in patients under nitrous oxide-oxygen-opioid anesthesia. Maximum changes at each dose are shown (n = 9 subjects per group). A, With fast injection, a 15% to 20% decrease in arterial pressure occurred at 2.5 to 3 × ED₉₅ (0.20 to 0.25 mg/kg). B, The changes were less than 10% when slower injection (30 seconds) was performed. (Redrawn from Savarese JJ, Ali HH, Basta SJ, et al: The cardiovascular effects of mivacurium chloride [BW B1090U] in patients receiving nitrous oxide-opiate-barbiturate anesthesia. Anesthesiology 70:386–394, 1989.)