Figure 12-13
Interaction at a 50% drug effect between propofol, midazolam,
and alfentanil. Downward deflection of the surface represents synergy, in units
of fractional reduction in C50
. The three edges represent relative amounts
of propofol to midazolam (thetaMid-Prop
), alfentanil to midazolam (thetaMid-Alf
),
and alfentanil to propofol (thetaAlf-Prop
). The surface between the
edges represents the relative synergy of all three drugs taken together. (From
Minto CF, Schnider TW, Short TG, et al: Response surface model for anesthetic drug
interactions. Anesthesiology 92:1603–1616, 2000.)
