Figure 11-25 A computer simulation of the context-sensitive half-times (50% decrement times) and 80% decrement times of fentanyl in animals with hemorrhagic shock and control animals. (From Egan TD, Kuramkote S, Gong G, et al: Fentanyl pharmacokinetics in hemorrhagic shock: A porcine model. Anesthesiology 91:156–166, 1999.)