Figure 11-21 A computer simulation of the context-sensitive half-times (50% decrement times) and 80% decrement times of remifentanil in obese versus lean subjects. Note that in clinical terms the curves are not grossly different in obese compared with lean subjects. (From Egan TD, Huizinga B, Gupta SK, et al: Remifentanil pharmacokinetics in obese versus lean patients. Anesthesiology 89:562–573, 1998.)