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Figure 11-19
Relationship between IC50
and age for fentanyl
and alfentanil. IC50
is the steady-state fentanyl or alfentanil serum
concentration that produces half the maximal spectral edge frequency decrease. (From
Scott JC, Stanski DR: Decreased fentanyl and alfentanil dose requirements with age.
A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp
Ther 240:159–166, 1987.)
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