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Figure 11-3
Intracellular signal transduction mechanisms linked with
the opioid receptors. Opioid agonists bind with the opioid receptors, leading to
activation of the G-protein. Activity of adenylate cyclase and the voltage-dependent
Ca2+
channels is suppressed. On the other hand, inward rectifier K+
channels and mitogen-activated protein kinase (MAPK) cascade are activated. AMP,
adenosine monophosphate; ATP, adenosine triphosphate.
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