Figure 10-16 A, Increase in PaCO₂ from baseline versus plasma concentration after three intravenous bolus doses of diazepam (0.15 mg/kg) given at 20-minute intervals. B, Increase in PaCO₂ from baseline versus the midazolam plasma concentration after three intravenous bolus doses of midazolam (0.05 mg/kg) given at 20-minute intervals. The solid line represents a best-fit model of the data from the three injections. Mean values are represented as plus or minus standard error of the mean. (Redrawn from Sunzel M, Paalzow L, Berggren L, Eriksson I: Respiratory and cardiovascular effects in relation to plasma levels of midazolam and diazepam. Br J Clin Pharmacol 25:561–569, 1988.)