Figure 7-16 A qualitative description of the effects of volatile anesthetics on the coronary blood flow (CBF)-diastolic pressure relationship demonstrates the effect of adenosine-induced maximal coronary vasodilation in awake and anesthetized dogs. Solid lines are mean slopes determined by linear regression analysis. Dashed lines represent the nonlinear portion of the curve and are estimates. When compared with the findings obtained in awake dogs, the anesthetics affect absolute CBF variably but do not increase the slope of the CBF-diastolic pressure plots. (Adapted from Hickey RF, Sybert PE, Verrier ED, Cason BA: Effects of halothane, enflurane, and isoflurane on coronary blood flow autoregulation and coronary vascular reserve in the canine heart. Anesthesiology 68:21–30, 1988.