Figure 5-19 Different times to awakening occur after 2, 4, or 8 hours of anesthesia at a 1.25 minimum alveolar concentration (MAC) for desflurane compared with sevoflurane. Awakening to response to command or to orientation is almost twice as rapid after anesthesia with the less soluble desflurane. (Adapted from Eger EI II, Gong D, Koblin DD, et al: Effect of anesthetic duration on kinetic and recovery characteristics of desflurane vs. sevoflurane (plus compound A) in volunteers. Anesth Analg 86:414–421, 1998.)