Other Compounds
Dezocine
Dezocine is slightly more potent and acts faster than morphine,
with a similar duration.[493]
Dezocine is a partial
agonist at μ- and probably δ-receptors. Side effects are similar to those
of morphine. It is more effective in reducing the MAC of potent inhaled anesthetics
(<50% with cyclopropane and 58% with enflurane) than other agonist-antagonists.
[494]
Dezocine can be effective for moderate and
severe pain,[495]
but it can cause myocardial depression
and hypotension.
Meptazinol
Meptazinol has been reported to cause minimal respiratory depression
because of its selectivity for μ1
-(high-affinity) receptors.[496]
However, meptazinol-induced respiratory depression has been also reported.[497]
There are conflicting reports concerning the efficacy of meptazinol
as a postoperative analgesic.[496]
Side effects
(nausea and vomiting) limit its use to relieve severe pain. Meptazinol, 120 mg,
is equianalgesic to 10 mg of morphine.
