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REFERENCES

1. Cohen MM, Duncan PG, Tate RB: Does anesthesia contribute to operative mortality? JAMA 260:2859–2863, 1988.

2. Fragen R: Diprivan (propofol): A historical perspective. Semin Anesth 7:1, 1988.

3. Kay B, Rolly G: I.C.I. 35868, a new intravenous induction agent. Acta Anaesthesiol Belg 28:303–316, 1977.

4. Briggs LP, Clarke RS, Watkins J: An adverse reaction to the administration of disoprofol (Diprivan). Anaesthesia 37:1099–1101, 1982.

5. James R, Glen JB: Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents. J Med Chem 23:1350–1357, 1980.

6. Simons P, Cockshott I, Douglas E: Blood concentrations, metabolism and elimination after a subanesthetic intravenous dose of (14)C-propofol (Diprivan) to male volunteers [abstract]. Postgrad Med J 61:64, 1985.

7. Veroli P, O'Kelly B, Bertrand F, et al: Extrahepatic metabolism of propofol in man during the anhepatic phase of orthotopic liver transplantation. Br J Anaesth 68:183–186, 1992.

8. Gray PA, Park GR, Cockshott ID, et al: Propofol metabolism in man during the anhepatic and reperfusion phases of liver transplantation. Xenobiotica 22:105–114, 1992.

9. Kuipers JA, Boer F, Olieman W, et al: First-pass lung uptake and pulmonary clearance of propofol: Assessment with a recirculatory indocyanine green pharmacokinetic model. Anesthesiology 91:1780–1787, 1999.

10. Dawidowicz AL, Fornal E, Mardarowicz M, Fijalkowska A: The role of human lungs in the biotransformation of propofol. Anesthesiology 93:992–997, 2000.

11. Raoof AA, van Obbergh LJ, de Ville de Goyet J, Verbeeck RK: Extrahepatic glucuronidation of propofol in man: Possible contribution of gut wall and kidney. Eur J Clin Pharmacol 50:91–96, 1996.

12. Chen TL, Ueng TH, Chen SH, et al: Human cytochrome P450 mono-oxygenase system is suppressed by propofol. Br J Anaesth 74:558–562, 1995.

13. Adam HK, Briggs LP, Bahar M, et al: Pharmacokinetic evaluation of ICI 35 868 in man. Single induction doses with different rates of injection. Br J Anaesth 55:97–103, 1983.

14. Kay NH, Sear JW, Uppington J, et al: Disposition of propofol in patients undergoing surgery. A comparison in men and women. Br J Anaesth 58:1075–1079, 1986.

15. Kirkpatrick T, Cockshott ID, Douglas EJ, Nimmo WS: Pharmacokinetics of propofol (Diprivan) in elderly patients. Br J Anaesth 60:146–150, 1988.

16. Gepts E, Camu F, Cockshott ID, Douglas EJ: Disposition of propofol administered as constant rate intravenous infusions in humans. Anesth Analg 66:1256–1263, 1987.

17. Schuttler J, Stoeckel H, Schwilden H: Pharmacokinetic and pharmacodynamic modeling of propofol ('Diprivan') in volunteers and surgical patients. Postgrad Med J 61 (Suppl 3):53–54, 1985.

18. Shafer A, Doze VA, Shafer SL, White PF: Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia. Anesthesiology 69:348–356, 1988.

19. Dyck JB, Maze M, Haack C, et al: Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology 78:821–828, 1993.

20. Venn RM, Karol MD, Grounds RM: Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care. Br J Anaesth 88:669–675, 2002.

21. Reves J: Benzodiazepines. In Prys-Roberts CH (ed): Pharmacokinetics of Anesthesia. Boston, Blackwell, 1984, p 157.

22. Fischler M, Bonnet F, Trang H, et al: The pharmacokinetics of droperidol in anesthetized patients. Anesthesiology 64:486–489, 1986.

23. Cressman WA, Plostnieks J, Johnson PC: Absorption, metabolism and excretion of droperidol by human subjects following intramuscular and intravenous administration. Anesthesiology 38:363–369, 1973.

24. Fragen RJ, Avram MJ, Henthorn TK, Caldwell NJ: A pharmacokinetically designed etomidate infusion regimen for hypnosis. Anesth Analg 62:654–660, 1983.

25. Schuttler J, Schwilden H, Stoeckel H: Infusion strategies to investigate the pharmacokinetics and pharmacodynamics of hypnotic drugs: Etomidate as an example. Eur J Anaesthesiol 2:133–142, 1985.

26. Hebron BS, Edbrooke DL, Newby DM, Mather SJ: Pharmacokinetics of etomidate associated with prolonged i.v. infusion. Br J Anaesth 55:281–287, 1983.

27. de Ruiter G, Popescu DT, de Boer AG, et al: Pharmacokinetics of etomidate in surgical patients. Arch Int Pharmacodyn Ther 249:180–188, 1981.

28. Van Hamme MJ, Ghoneim MM, Ambre JJ: Pharmacokinetics of etomidate, a new intravenous anesthetic. Anesthesiology 49:274–277, 1978.

29. Forster A, Gardaz JP, Suter PM, Gemperle M: I.V. midazolam as an induction agent for anaesthesia: A study in volunteers. Br J Anaesth 52:907–911, 1980.

30. Norton AC, Dundas CR: Induction agents for day-case anaesthesia. A double-blind comparison of propofol and midazolam antagonised by flumazenil. Anaesthesia 45:198–203, 1990.

31. Clements JA, Nimmo WS: Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 53:27–30, 1981.

32. Bremier D: Pharmacokinetics of methohexitone following intravenous infusions in humans. Br J Anaesth 48:643, 1976.

33. Hudson RJ, Stanski DR, Burch PG: Pharmacokinetics of methohexital and thiopental in surgical patients. Anesthesiology 59:215–219, 1983.

34. Philip BK, Simpson TH, Hauch MA, Mallampati SR: Flumazenil reverses sedation after midazolam-induced general anesthesia in ambulatory surgery patients. Anesth Analg 71:371–376, 1990.


363


35. Mandema JW, Tuk B, van Steveninck AL, et al: Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers. Clin Pharmacol Ther 51:715–728, 1992.

36. Bauer TM, Ritz R, Haberthur C, et al: Prolonged sedation due to accumulation of conjugated metabolites of midazolam. Lancet 346:145–147, 1995.

37. Greenblatt DJ, Shader RI, Divoll M, Harmatz JS: Benzodiazepines: A summary of pharmacokinetic properties. Br J Clin Pharmacol 11(Suppl 1):11S–16S, 1981.

38. MacLeod SM, Giles HG, Bengert B, et al: Age- and gender-related differences in diazepam pharmacokinetics. J Clin Pharmacol 19:15–19, 1979.

39. Greenblatt DJ, Abernethy DR, Locniskar A, et al: Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology 61:27–35, 1984.

40. Mould DR, DeFeo TM, Reele S, et al: Simultaneous modeling of the pharmacokinetics and pharmacodynamics of midazolam and diazepam. Clin Pharmacol Ther 58:35–43, 1995.

41. Bischoff KB, Dedrick RL: Thiopental pharmacokinetics. J Pharm Sci 57:1346–1351, 1968.

42. Christensen J, Andreasen F, Jansen J: Pharmacokinetics of thiopentone in a group of young women and a group of young men. Br J Anaesth 52:913–918, 1980.

43. Bailie GR, Cockshott ID, Douglas EJ, Bowles BJ: Pharmacokinetics of propofol during and after long-term continuous infusion for maintenance of sedation in ICU patients. Br J Anaesth 68:486–491, 1992.

44. Hughes MA, Glass PS, Jacobs JR: Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology 76:334–341, 1992.

45. Dyck J, Varvel J, Hung O: The pharmacokinetics of propofol vs. age. Anesthesiology 75:A315, 1991.

46. Kazama T, Ikeda K, Morita K, et al: Comparison of the effect-site k(e0)s of propofol for blood pressure and EEG bispectral index in elderly and younger patients. Anesthesiology 90:1517–1527, 1999.

47. Schnider TW, Minto CF, Shafer SL, et al: The influence of age on propofol pharmacodynamics. Anesthesiology 90:1502–1516, 1999.

48. Servin F, Desmonts JM, Farinotti R, et al: Pharmacokinetics of the continuous infusion of propofol in the cirrhotic patient. Preliminary results [in French]. Ann Fr Anesth Reanim 6:228–289, 1987.

49. Morcos WE, Payne J: The induction of anaesthesia with propofol ('Diprivan') compared in normal and renal failure patients. Postgrad Med J 61(Suppl 3):62–63, 1985.

50. Leslie K, Sessler DI, Bjorksten AR, Moayeri A: Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. Anesth Analg 80:1007–1014, 1995.

51. Upton RN, Ludbrook GL, Grant C, Martinez AM: Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration. Anesth Analg 89:545–552, 1999.

52. Kurita T, Morita K, Kazama T, Sato S: Influence of cardiac output on plasma propofol concentrations during constant infusion in swine. Anesthesiology 96:1498–1503, 2002.

53. Kazama T, Kurita T, Morita K, et al: Influence of hemorrhage on propofol pseudo-steady state concentration. Anesthesiology 97:1156–1161, 2002.

54. Bailey JM, Mora CT, Shafer SL: Pharmacokinetics of propofol in adult patients undergoing coronary revascularization. The Multicenter Study of Perioperative Ischemia Research Group. Anesthesiology 84:1288–1297, 1996.

55. Marsh B, White M, Morton N, Kenny GN: Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth 67:41–48, 1991.

56. Kataria BK, Ved SA, Nicodemus HF, et al: The pharmacokinetics of propofol in children using three different data analysis approaches. Anesthesiology 80:104–122, 1994.

57. Murat I, Billard V, Vernois J, et al: Pharmacokinetics of propofol after a single dose in children aged 1–3 years with minor burns. Comparison of three data analysis approaches. Anesthesiology 84:526–532, 1996.

58. Benoni G, Cuzzolin L, Gilli E: Pharmacokinetics of propofol: Influence of fentanyl administration [abstract]. Eur J Anaesthesiol 183:1457, 1990.

59. Pavlin DJ, Coda B, Shen DD, et al: Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers. Anesthesiology 84:23–37, 1996.

60. Gill SS, Wright EM, Reilly CS: Pharmacokinetic interaction of propofol and fentanyl: Single bolus injection study. Br J Anaesth 65:760–765, 1990.

61. Matot I, Neely CF, Katz RY, Marshall BE: Fentanyl and propofol uptake by the lung: Effect of time between injections. Acta Anaesthesiol Scand 38:711–715, 1994.

62. Janicki PK, James MF, Erskine WA: Propofol inhibits enzymatic degradation of alfentanil and sufentanil by isolated liver microsomes in vitro. Br J Anaesth 68:311–312, 1992.

63. Krasowski MD, Nishikawa K, Nikolaeva N, et al: Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics. Neuropharmacology 41:952–964, 2001.

64. Jurd R, Arras M, Lambert S, Drexler B: General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor beta3 subunit. FASEB J 17:250–252, 2003.

65. Lam DW, Reynolds JN: Modulatory and direct effects of propofol on recombinant GABAA receptors expressed in Xenopus oocytes: Influence of alpha- and gamma2 -subunits. Brain Res 784:179–187, 1998.

66. Kikuchi T, Wang Y, Sato K, Okumura F: In vivo effects of propofol on acetylcholine release from the frontal cortex, hippocampus and striatum studied by intracerebral microdialysis in freely moving rats. Br J Anaesth 80:644–648, 1998.

67. Pain L, Jeltsch H, Lehmann O, et al: Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats. Br J Anaesth 85:869–873, 2000.

68. Kushikata T, Hirota K, Yoshida H, et al: Alpha-2 adrenoceptor activity affects propofol-induced sleep time. Anesth Analg 94:1201–1206, 2002.

69. Lingamaneni R, Birch ML, Hemmings HC Jr: Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol. Anesthesiology 95:1460–1466, 2001.

70. Antognini J, Wang X, Piercy M, Carstens E: Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats. Can J Anaesth 47:273–279, 2000.

71. Dong XP, Xu TL: The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Anesth Analg 95:907–914, 2002.

72. Tonner PH, Poppers DM, Miller KW: The general anesthetic potency of propofol and its dependence on hydrostatic pressure. Anesthesiology 77:926–931, 1992.

73. Briggs LP, Dundee JW, Bahar M, Clarke RS: Comparison of the effect of diisopropyl phenol (ICI 35,868) and thiopentone on response to somatic pain. Br J Anaesth 54:307–311, 1982.

74. Canavero S, Bonicalzi V, Pagni CA, et al: Propofol analgesia in central pain: Preliminary clinical observations. J Neurol 242:561–567, 1995.

75. Pain L, Gobaille S, Schleef C, et al: In vivo dopamine measurements in the nucleus accumbens after nonanesthetic and anesthetic doses of propofol in rats. Anesth Analg 95:915–919, 2002.

76. Cechetto DF, Diab T, Gibson CJ, Gelb AW: The effects of propofol in the area postrema of rats. Anesth Analg 92:934–942, 2001.

77. Major E, Verniquet AJ, Waddell TK, et al: A study of three doses of ici 35 868 for induction and maintenance of anaesthesia. Br J Anaesth 53:267–272, 1981.

78. Rolly G, Versichelen L, Huyghe L, Mungroop H: Effect of speed of injection on induction of anaesthesia using propofol. Br J Anaesth 57:743–746, 1985.
364


79. Glass P, Ginsberg B, Hawkins E: Comparison of sodium thiopental/isoflurane to propofol (delivered by means of a pharmacokinetic model-driven device) for the induction, maintenance, and recovery from anesthesia. Anesthesiology 69:A575, 1988.

80. McClune S, McKay AC, Wright PM, et al: Synergistic interaction between midazolam and propofol. Br J Anaesth 68:240–245, 1992.

81. Short TG, Plummer JL, Chui PT: Hypnotic and anaesthetic interactions between midazolam, propofol and alfentanil. Br J Anaesth 69:162–167, 1992.

82. Adam HK, Kay B, Douglas EJ: Blood disoprofol levels in anesthetised patients. Correlation of concentrations after single or repeated doses with hypnotic activity. Anaesthesia 37:536–540, 1982.

83. Aun CS, Short SM, Leung DH, Oh TE: Induction dose-response of propofol in unpremedicated children. Br J Anaesth 68:64–67, 1992.

84. Smith C, McEwan A, Jhaveri R: Reduction of propofol Cp50 by fentanyl. Anesthesiology 81:820–828, 1994.

85. Mackenzie N, Grant IS: Propofol for intravenous sedation. Anaesthesia 42:3–6, 1987.

86. Wilson E, Mackenzie N, Grant IS: A comparison of propofol and midazolam by infusion to provide sedation in patients who receive spinal anaesthesia. Anaesthesia 43(Suppl):91–94, 1988.

87. Veselis RA, Reinsel RA, Wronski M, et al: EEG and memory effects of low-dose infusions of propofol. Br J Anaesth 69:246–254, 1992.

88. Zacny JP, Lichtor JL, Coalson DW, et al: Subjective and psychomotor effects of subanesthetic doses of propofol in healthy volunteers. Anesthesiology 76:696–702, 1992.

89. Kelly JS, Roy RC: Intraoperative awareness with propofol-oxygen total intravenous anesthesia for microlaryngeal surgery. Anesthesiology 77:207–209, 1992.

90. Glass PS: Prevention of awareness during total intravenous anesthesia. Anesthesiology 78:399–400, 1993.

91. McDonald NJ, Mannion D, Lee P, et al: Mood evaluation and outpatient anaesthesia. A comparison between propofol and thiopentone. Anaesthesia 43(Suppl):68–69, 1988.

92. Nelson V: Hallucinations after propofol. Anaesthesia 43:170, 1988.

93. Cameron A: Opisthotonos again. Anaesthesia 42:1124, 1987.

94. Hazeaux C, Tisserant D, Vespignani H, et al: Electroencephalographic changes produced by propofol [in French]. Ann Fr Anesth Reanim 6:261–266, 1987.

95. Yate PM, Maynard DE, Major E, et al: Anaesthesia with ICI 35,868 monitored by the cerebral function analysing monitor (CFAM). Eur J Anaesthesiol 3:159–166, 1986.

96. Glass PS, Bloom M, Kearse L, et al: Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers. Anesthesiology 86:836–847, 1997.

97. Maurette P, Simeon F, Castagnera L, et al: Propofol anaesthesia alters somatosensory evoked cortical potentials. Anaesthesia 43(Suppl):44–45, 1988.

98. Savoia G, Esposito C, Belfiore F, et al: Propofol infusion and auditory evoked potentials. Anaesthesia 43(Suppl):46–49, 1988.

99. Doi M, Gajraj RJ, Mantzaridis H, Kenny GN: Relationship between calculated blood concentration of propofol and electrophysiological variables during emergence from anaesthesia: Comparison of bispectral index, spectral edge frequency, median frequency and auditory evoked potential index. Br J Anaesth 78:180–184, 1997.

100. Glen JB, Hunter SC, Blackburn TP, Wood P: Interaction studies and other investigations of the pharmacology of propofol ('Diprivan'). Postgrad Med J 61(Suppl 3):7–14, 1985.

101. al-Hader A, Hasan M, Hasan Z: The comparative effects of propofol, thiopental, and diazepam, administered intravenously, on pentylenetetrazol seizure threshold in the rabbit. Life Sci 51:779–786, 1992.

102. Heavner J, Arthur J, Zou J: Propofol vs. thiopental for treating bupivacaine induced seizures in rats. Anesthesiology 77:A802, 1992.

103. Wood P, Browne G, Pugh S: Propofol infusion for the treatment of status epilepticus [letter]. Lancet 1:480, 1988.

104. Chilvers CR, Laurie PS: Successful use of propofol in status epilepticus. Anaesthesia 45:995–996, 1990.

105. Dwyer R, McCaughey W, Lavery J, et al: Comparison of propofol and methohexitone as anaesthetic agents for electroconvulsive therapy. Anaesthesia 43:459–462, 1988.

106. Hodkinson BP, Frith RW, Mee EW: Propofol and the electroencephalogram. Lancet 2:1518, 1987.

107. Committee on Safety of Medicines: Propofol. Curr Probl 20, 1987.

108. Ebrahim ZY, Schubert A, Van Ness P, et al: The effect of propofol on the electroencephalogram of patients with epilepsy. Anesth Analg 78:275–279, 1994.

109. Samra SK, Sneyd JR, Ross DA, Henry TR: Effects of propofol sedation on seizures and intracranially recorded epileptiform activity in patients with partial epilepsy. Anesthesiology 82:843–851, 1995.

110. Anonymous: Convulsions after propofol. Pharm J 249:745, 1992.

111. Deer TR, Rich GF: Propofol tolerance in a pediatric patient. Anesthesiology 77:828–829, 1992.

112. Boyle W, Shear J, White P: Tolerance and hyperlipemia during long term sedation with propofol. Anesthesiology 73:A245, 1990.

113. Follette JW, Farley WJ: Anesthesiologist addicted to propofol. Anesthesiology 77:817–818, 1992.

114. Mendes PM, Silberstein SD, Young WB, et al: Intravenous propofol in the treatment of refractory headache. Headache 42:638–641, 2002.

115. Stephan H, Sonntag H, Schenk HD, Kohlhausen S: Effect of Disoprivan (propofol) on the circulation and oxygen consumption of the brain and CO2 reactivity of brain vessels in the human [in German]. Anaesthesist 36:60–65, 1987.

116. Hartung HJ: Intracranial pressure in patients with craniocerebral trauma after administration of propofol and thiopental [in German]. Anaesthesist 36:285–287, 1987.

117. Hartung HJ: Modification of intracranial pressure by propofol (Disoprivan). Initial results [in German]. Anaesthesist 36:66–68, 1987.

118. Ravussin P, Guinard JP, Ralley F, Thorin D: Effect of propofol on cerebrospinal fluid pressure and cerebral perfusion pressure in patients undergoing craniotomy. Anaesthesia 43(Suppl):37–41, 1988.

119. Vandesteene A, Trempont V, Engelman E, et al: Effect of propofol on cerebral blood flow and metabolism in man. Anaesthesia 43(Suppl):42–43, 1988.

120. Herregods L, Verbeke J, Rolly G, Colardyn F: Effect of propofol on elevated intracranial pressure. Preliminary results. Anaesthesia 43(Suppl):107–109, 1988.

121. Mirakhur R, Shepherd W: Intraocular pressure changes with propofol ('Diprivan'): Comparison with thiopentone. Postgrad Med J 61(Suppl 3):41–44, 1985.

122. Mirakhur RK, Shepherd WF, Darrah WC: Propofol or thiopentone: Effects on intraocular pressure associated with induction of anaesthesia and tracheal intubation (facilitated with suxamethonium). Br J Anaesth 59:431–436, 1987.

123. Enns J, Gelb A, Manninen P: Cerebral autoregulation is maintained during propofol-nitrous oxide anaesthesia in humans. Can J Anaesth 39:A43, 1992.

124. Jansen G, Kagenaar D, Kedaria M: Effects of propofol on the relation between CO2 and cerebral blood flow velocity. Anesth Analg 76:S163, 1993.

125. Newman MF, Murkin JM, Roach G, et al: Cerebral physiologic effects of burst suppression doses of propofol during nonpulsatile cardiopulmonary bypass. CNS Subgroup of McSPI. Anesth Analg 81:452–457, 1995.

126. Kochs E, Hoffman WE, Werner C, et al: The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats. Anesthesiology 76:245–252, 1992.
365


127. Gelb A, Zhang C, Henderson S: A comparison of the cerebral protective effects of propofol, thiopental, and halothane in temporary feline focal cerebral ischemia. Anesth Analg 76:S115, 1993.

128. Ridenour TR, Warner DS, Todd MM, Gionet TX: Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat. Anesthesiology 76:807–812, 1992.

129. Gelb AW, Bayona NA, Wilson JX, Cechetto DF: Propofol anesthesia compared to awake reduces infarct size in rats. Anesthesiology 96:1183–1190, 2002.

130. Bhardwaj A, Castro IA, Alkayed NJ, et al: Anesthetic choice of halothane versus propofol: Impact on experimental perioperative stroke. Stroke 32:1920–1925, 2001.

131. Kaptanoglu E, Sen S, Beskonakli E, et al: Antioxidant actions and early ultrastructural findings of thiopental and propofol in experimental spinal cord injury. J Neurosurg Anesthesiol 14:114–122, 2002.

132. Amorim P, Chambers G, Cottrell J, Kass IS: Propofol reduces neuronal transmission damage and attenuates the changes in calcium, potassium, and sodium during hyperthermic anoxia in the rat hippocampal slice. Anesthesiology 83:1254–1265, 1995.

133. Ergun R, Adkemir G, Sen S, et al: Neuroprotective effects of propofol following global cerebral ischemia in rats. Neurosurg Rev 25:95–98, 2002.

134. Lanigan C, Sury M, Bingham R, et al: Neurological sequelae in children after prolonged propofol infusion. Anaesthesia 47:810–811, 1992.

135. Trotter C, Serpell MG: Neurological sequelae in children after prolonged propofol infusion. Anaesthesia 47:340–342, 1992.

136. Spahr-Schopfer I, Vutskits L, Toni N, et al: Differential neurotoxic effects of propofol on dissociated cortical cells and organotypic hippocampal cultures. Anesthesiology 92:1408–1417, 2000.

137. Vuyk J, Engbers FH, Lemmens HJ, et al: Pharmacodynamics of propofol in female patients. Anesthesiology 77:3–9, 1992.

138. Forrest FC, Tooley MA, Saunders PR, Prys-Roberts C: Propofol infusion and the suppression of consciousness: The EEG and dose requirements. Br J Anaesth 72:35–41, 1994.

139. Turtle MJ, Cullen P, Prys-Roberts C, et al: Dose requirements of propofol by infusion during nitrous oxide anaesthesia in man. II: Patients premedicated with lorazepam. Br J Anaesth 59:283–287, 1987.

140. Spelina KR, Coates DP, Monk CR, et al: Dose requirements of propofol by infusion during nitrous oxide anaesthesia in man. I: Patients premedicated with morphine sulphate. Br J Anaesth 58:1080–1084, 1986.

141. Sanderson JH, Blades JF: Multicentre study of propofol in day case surgery. Anaesthesia 43(Suppl):70–73, 1988.

142. Kazama T, Ikeda K, Morita K, Sanjo Y: Awakening propofol concentration with and without blood-effect site equilibration after short-term and long-term administration of propofol and fentanyl anesthesia. Anesthesiology 88:928–934, 1998.

143. Taylor MB, Grounds RM, Mulrooney PD, Morgan M: Ventilatory effects of propofol during induction of anaesthesia. Comparison with thiopentone. Anaesthesia 41:816–820, 1986.

144. Goodman NW, Black AM, Carter JA: Some ventilatory effects of propofol as sole anaesthetic agent. Br J Anaesth 59:1497–1503, 1987.

145. Gold MI, Abraham EC, Herrington C: A controlled investigation of propofol, thiopentone and methohexitone. Can J Anaesth 34:478–483, 1987.

146. Munson ES, Larson CP Jr, Babad AA, et al: The effects of halothane, fluroxene and cyclopropane on ventilation: A comparative study in man. Anesthesiology 27:716–728, 1966.

147. Knill RL, Clement JL, Gelb AW: Ventilatory responses mediated by peripheral chemoreceptors in anaesthetized man. Adv Exp Med Biol 99:66–77, 1978.

148. Aun C, Major E: The cardiorespiratory effects of ICI 35 868 in patients with valvular heart disease. Anaesthesia 39:1096–1100, 1984.

149. Grounds RM, Twigley AJ, Carli F, et al: The haemodynamic effects of intravenous induction. Comparison of the effects of thiopentone and propofol. Anaesthesia 40:735–740, 1985.

150. Al-Khudhairi D, Gordon G, Morgan M, Whitwam JG: Acute cardiovascular changes following disoprofol. Effects in heavily sedated patients with coronary artery disease. Anaesthesia 37:1007–1010, 1982.

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