Aftermath
It is remarkable that without more explicit instructions or an
actual demonstration by one of the Boston group, ether anesthesia was adopted so
rapidly around the world. Only 63 days after the Morton demonstration, ether was
administered in England by James Robinson (1813–1862), a prominent London dentist,
for extraction of a deep-seated molar in a 13-year-old girl. Robinson had learned
of ether anesthesia through a letter shown to him by a neighboring friend, Francis
Boott, who had received the letter from Jacob Bigelow, father of Henry Bigelow, describing
the effects of ether inhalation. Robinson devised a new inhaler and wrote the first
textbook on anesthesia, which was published in London on March 1, 1847.[121]
Two days after Robinson's use of ether, Robert Liston (1794–1847) performed
the first operation in England—a leg amputation at University College Hospital,
London—with ether as the anesthetic delivered by William Squire. Within a
few months, ether anesthesia had spread to the European continent. Nikolai Ivanovitch
Pirogoff (1810–1881) used ether in St. Petersburg as early as February 1847,
and he wrote a treatise on the subject.[122]
Of
significant importance for the widespread use of ether was the prestige of the Boston
surgeons, who firmly supported its legitimacy.
Many who tried to administer the anesthetic did so without proper
preparation, and failures were common. Several questions remained unanswered. Bigelow's
article was vague about how it should be administered, simply describing a number
of cases with the use of Morton's inhaler. How the ether was supposed to be administered
after the loss of consciousness was not addressed.
Nasal breathing or failure to purse the lips around the mouthpiece must have placed
a limit on the duration of effective vapor administration. It was another lucky
circumstance for Morton that ether was chosen as his agent. Subsequent studies with
ether have revealed that it stimulates the sympathetic nervous system at deep levels
of anesthesia.[123]
This unique property of the
drug and its high blood solubility result in a remarkably safe agent, requiring only
marginal skills to avoid overdose.